Dengue fever often hits tropical climates, such as Indonesia. The high number of dengue cases makes many researchers try to develop the most effective vaccine to prevent this disease. However, the dengue vaccine apparently still has some shortcomings. Dengue fever (DHF) is a disease caused by dengue virus infection, this disease is transmitted through the bite of the Aedes aegypti mosquito. Usually, dengue fever occurs during the rainy season. This is because high rainfall allows mosquitoes to breed well. DHF has several symptoms, such as high fever, skin rash, bone or muscle pain, and headaches in the back of the eye. In severe cases, bleeding can also occur that can be life threatening. The World Health Organization (WHO) reports that around 20,000 people die each year from dengue fever. Get to know the Dengue Fever Vaccine The available dengue vaccine is the CYD-TDV (Dengvaxia) vaccine. This vaccine contains a weakened tetravalent dengue virus. Tetravalent here means that the